CD8+ T Lymphocytes and Macrophages Infiltrate Coronary Artery Aneurysms in Acute Kawasaki Disease

@article{Brown2001CD8TL,
  title={CD8+ T Lymphocytes and Macrophages Infiltrate Coronary Artery Aneurysms in Acute Kawasaki Disease},
  author={Timothy J Brown and Susan E Crawford and Mona L Cornwall and Francesca Garcia and Stanford T. Shulman and Anne H. Rowley},
  journal={Pediatric Research},
  year={2001},
  volume={53},
  pages={161-161}
}
The pathogenesis of coronary arterial inflammation in acute Kawasaki Disease (KD) is unclear. Immunophenotypic characterization of the inflammatory cells in the KD vascular lesion has been reported previously in only a single case, by Terai and colleagues. To test the hypothesis that the vascular lesion in KD is an activated T lymphocyte-dependent process, we performed immunohistochemical studies on coronary artery aneurysms from eight fatal acute KD cases using antibodies to CD45RO (activated… CONTINUE READING
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