CD8+ T Lymphocyte Expansion, Proliferation and Activation in Dengue Fever

  title={CD8+ T Lymphocyte Expansion, Proliferation and Activation in Dengue Fever},
  author={Andr{\'e}ia Manso de Matos and Karina In{\'a}cio Carvalho and Daniela Santoro Rosa and Lucy Santos Villas-Boas and Wanessa Cardoso da Silva and C{\'e}lia Luiza de Lima Rodrigues and Ol{\'i}mpia Massae Nakasone Peel Furtado Oliveira and Jos{\'e} Eduardo Levi and Evaldo Stanislau Affonso de Ara{\'u}jo and Cl{\'a}udio S{\'e}rgio Pannuti and Expedito Jos{\'e} de Albuquerque Luna and Esper George Kallas},
  booktitle={PLoS neglected tropical diseases},
Dengue fever induces a robust immune response, including massive T cell activation. The level of T cell activation may, however, be associated with more severe disease. In this study, we explored the level of CD8+ T lymphocyte activation in the first six days after onset of symptoms during a DENV2 outbreak in early 2010 on the coast of São Paulo State, Brazil. Using flow cytometry we detected a progressive increase in the percentage of CD8+ T cells in 74 dengue fever cases. Peripheral blood… CONTINUE READING
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Comprehensive analysis of dengue virus-specific responses supports an HLA-linked protective role for CD8+ T cells

  • D Weiskopf, MA Angelo, EL de Azeredo, J Sidney, JA Greenbaum
  • Proc Natl Acad Sci U S A 110: E2046–2053. doi: 10…
  • 2013
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