Proinflammatory adaptive immune responses are recognized as major drivers of atherosclerotic lesion formation. Although CD8(+) T cells have recently been proposed as a proatherogenic cell subset, their full scope of actions remains to be elucidated.
We here addressed the contribution of CD8(+) T cells to monocyte trafficking in… (More)
Figure 4. CD8+ T-cell depletion does not affect monocyte recruitment to atherosclerotic vessels. A, Representative dot plots (pregated on CD11b+ cells) of single cell suspensions obtained from vessels (aorta and aortic sinus) of control and anti–CD8α-treated mice that were injected with CD45.1 bone marrow mononuclear cells. Data from all mice per group were pooled for illustrative dot plots. B, Quantitative analysis of the number of recruited CD45.1+CD45.2CD11b+Ly6G- monocytes in vessels of control and anti–CD8α-treated mice (n=7 per group).