CD8+ T Cells Cause Disability and Axon Loss in a Mouse Model of Multiple Sclerosis

  title={CD8+ T Cells Cause Disability and Axon Loss in a Mouse Model of Multiple Sclerosis},
  author={Chandra Deb and Reghann G. LaFrance-Corey and William F. Schmalstieg and Brian M. Sauer and Huan Wang and Christopher L. German and Anthony J Windebank and Moses Rodriguez and Charles L Howe},
  booktitle={PloS one},
BACKGROUND The objective of this study was to test the hypothesis that CD8+ T cells directly mediate motor disability and axon injury in the demyelinated central nervous system. We have previously observed that genetic deletion of the CD8+ T cell effector molecule perforin leads to preservation of motor function and preservation of spinal axons in chronically demyelinated mice. METHODOLOGY/PRINCIPAL FINDINGS To determine if CD8+ T cells are necessary and sufficient to directly injure… CONTINUE READING
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The challenge of multiple sclerosis: how do we cure a chronic heterogeneous disease

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  • Ann Neurol
  • 2009
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