CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells.

@article{Yamazaki2008CD8CS,
  title={CD8+ CD205+ splenic dendritic cells are specialized to induce Foxp3+ regulatory T cells.},
  author={Sayuri Yamazaki and Diana Dudziak and Gordon F Heidkamp and Christopher J. Fiorese and Anthony J. Bonito and Kayo Inaba and Michel C. Nussenzweig and Ralph Marvin Steinman},
  journal={Journal of immunology},
  year={2008},
  volume={181 10},
  pages={6923-33}
}
Foxp3(+)CD25(+)CD4(+) regulatory T cells (Treg) mediate immunological self-tolerance and suppress immune responses. A subset of dendritic cells (DCs) in the intestine is specialized to induce Treg in a TGF-beta- and retinoic acid-dependent manner to allow for oral tolerance. In this study we compare two major DC subsets from mouse spleen. We find that CD8(+) DEC-205/CD205(+) DCs, but not the major fraction of CD8(-) DC inhibitory receptor-2 (DCIR2)(+) DCs, induce functional Foxp3(+) Treg from… CONTINUE READING
Highly Influential
This paper has highly influenced 16 other papers. REVIEW HIGHLY INFLUENTIAL CITATIONS
154 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 154 extracted citations

Similar Papers

Loading similar papers…