CD8(+) T cells: foot soldiers of the immune system.

@article{Zhang2011CD8TC,
  title={CD8(+) T cells: foot soldiers of the immune system.},
  author={Nu Zhang and Michael John Bevan},
  journal={Immunity},
  year={2011},
  volume={35 2},
  pages={161-8}
}
Resting naive CD8(+) T cells have an astounding capacity to react to pathogens by massive expansion and differentiation into cytotoxic effector cells that migrate to all corners of the body to clear the infection. The initial interaction with antigen-presenting cells in the central lymphoid organs drives an orchestrated program of differentiation aimed at producing sufficient numbers of effectors to get the job done without resulting in clonal exhaustion. Interactions with antigen-presenting… CONTINUE READING
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