CD74 is expressed by multiple myeloma and is a promising target for therapy.

@article{Burton2004CD74IE,
  title={CD74 is expressed by multiple myeloma and is a promising target for therapy.},
  author={Jack D Burton and Scott Ely and P. Ram Kishore Kumar Reddy and Rhona Stein and David V. Gold and Thomas M. Cardillo and David M. Goldenberg},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 19},
  pages={6606-11}
}
PURPOSE CD74 (HLA-DR-associated invariant chain) plays a role in antigen presentation. In addition to its expression on antigen-presenting cells, it is expressed by carcinomas of renal, lung, gastric, and thymic origin and by certain sarcomas. The restricted expression of CD74 by normal tissues and its very rapid internalization make CD74 an attractive therapeutic target for both cancer and immunologic diseases. Preclinical efficacy of anti-CD74 monoclonal antibody (mAb) therapy has been… CONTINUE READING

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