CD73-generated adenosine promotes osteoblast differentiation.

@article{Takedachi2012CD73generatedAP,
  title={CD73-generated adenosine promotes osteoblast differentiation.},
  author={Masahide Takedachi and Hiroyuki Oohara and Brenda J Smith and Mitsuyoshi Iyama and Mariko Kobashi and Kenichiro Maeda and Courtney L Long and Mary Beth Humphrey and Barbara J. Stoecker and Satoru Toyosawa and Linda F. Thompson and Shinya Murakami},
  journal={Journal of cellular physiology},
  year={2012},
  volume={227 6},
  pages={2622-31}
}
CD731 is a GPI-anchored cell surface protein with ecto-5'-nucleotidase enzyme activity that plays a crucial role in adenosine production. While the roles of adenosine receptors (AR) on osteoblasts and osteoclasts have been unveiled to some extent, the roles of CD73 and CD73-generated adenosine in bone tissue are largely unknown. To address this issue, we first analyzed the bone phenotype of CD73-deficient (cd73(-/-)) mice. The mutant male mice showed osteopenia, with significant decreases of… CONTINUE READING

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