CD73-generated adenosine promotes osteoblast differentiation.

  title={CD73-generated adenosine promotes osteoblast differentiation.},
  author={Masahide Takedachi and Hiroyuki Oohara and Brenda J Smith and Mitsuyoshi Iyama and Mariko Kobashi and Kenichiro Maeda and Courtney L Long and Mary Beth Humphrey and Barbara J. Stoecker and Satoru Toyosawa and Linda F. Thompson and Shinya Murakami},
  journal={Journal of cellular physiology},
  volume={227 6},
CD731 is a GPI-anchored cell surface protein with ecto-5'-nucleotidase enzyme activity that plays a crucial role in adenosine production. While the roles of adenosine receptors (AR) on osteoblasts and osteoclasts have been unveiled to some extent, the roles of CD73 and CD73-generated adenosine in bone tissue are largely unknown. To address this issue, we first analyzed the bone phenotype of CD73-deficient (cd73(-/-)) mice. The mutant male mice showed osteopenia, with significant decreases of… CONTINUE READING


Publications citing this paper.
Showing 1-10 of 38 extracted citations


Publications referenced by this paper.
Showing 1-10 of 42 references

On the role of subtype selective adenosine receptor agonists during proliferation and osteogenic differentiation of human primary bone marrow stromal cells

  • T Eckle, T Krahn, +8 authors H Eltzschig
  • J Cell Physiol
  • 2011

Adenosine A 2 A receptors play an active role in mouse bone marrow - derived mesenchymal stem cell development

  • P Lennon, C Taylor, G Stahl, S Colgan
  • J Leukoc Biol
  • 2009

Expression , signaling , and function of P 2 X 7 receptors in bone

  • G Haskó, J Linden, B Cronstein, P Pacher
  • Purinergic Signal
  • 2009

Similar Papers

Loading similar papers…