CD73 Pathway Contributes to the Immunosuppressive Ability of Mesenchymal Stem Cells in Intraocular Autoimmune Responses.

@article{Chen2016CD73PC,
  title={CD73 Pathway Contributes to the Immunosuppressive Ability of Mesenchymal Stem Cells in Intraocular Autoimmune Responses.},
  author={Xiteng Chen and Hui Shao and Yuntao Zhi and Qing Xiao and Chang Su and Lijie Dong and Xun Liu and Xiaorong Li and Xiaomin Zhang},
  journal={Stem cells and development},
  year={2016},
  volume={25 4},
  pages={337-46}
}
Mesenchymal stem cells (MSCs) exhibit a potent immunomodulatory capacity and have been applied to treat diseases such as graft versus host disease and severe autoimmune diseases. However, the mechanism underlying their immunosuppressive effect is not yet completely understood. Here, we investigated the role of the CD73/adenosine pathway in immune modulation by MSCs using a mouse model of experimental autoimmune uveitis (EAU). Moreover, we examined the in vitro modulatory effect of MSCs mediated… CONTINUE READING
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