CD73 Activity is Dispensable for the Polarization of M2 Macrophages

Abstract

The ectoenzyme CD73 catalyzes the hydrolysis of AMP, and is one of the most important producers of extracellular adenosine. On regulatory T cells, CD73 is necessary for immunosuppressive functions, and on Th17 cells CD73-generated adenosine exerts anti-inflammatory effects. However, the expression and function of CD73 in pro-inflammatory M1 and in… (More)
DOI: 10.1371/journal.pone.0134721

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