CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation.

@article{Pan1999CD72deficientMR,
  title={CD72-deficient mice reveal nonredundant roles of CD72 in B cell development and activation.},
  author={Chong-xian Pan and Nicole Baumgarth and Jane R. Parnes},
  journal={Immunity},
  year={1999},
  volume={11 4},
  pages={495-506}
}
CD72, a B cell surface protein of the C-type lectin superfamily, recruits the tyrosine phosphatase SHP-1 through its ITIM motif(s). Using CD72-deficient (CD72-/-) mice, we demonstrate that CD72 is a nonredundant regulator of B cell development. In the bone marrow of CD72-/- mice, there was a reduction in the number of mature recirculating B cells and an accumulation of pre-B cells. In the periphery of CD72-/- mice, there were fewer mature B-2 cells and more B-1 cells. In addition, CD72 is a… CONTINUE READING