CD72, a negative regulator of B-cell responsiveness.

  title={CD72, a negative regulator of B-cell responsiveness.},
  author={Jane R. Parnes and Caobing Pan},
  journal={Immunological reviews},
The ability of lymphocytes to respond to antigenic or mitogenic stimulation is regulated not only by specific receptor proteins, but also by both positive and negative regulatory proteins that set or fine-tune the threshold for responsiveness. CD72 is one such regulatory protein on B lymphocytes. It is a member of the C-type lectin superfamily and is expressed on the surface of B cells from the pro-B through the mature B-cell stage. Studies with anti-CD72 antibodies have suggested a positive… CONTINUE READING
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