CD69 expression during selection and maturation of CD4+8+ thymocytes.

@article{Swat1993CD69ED,
  title={CD69 expression during selection and maturation of CD4+8+ thymocytes.},
  author={Wojciech Swat and Mark Dessing and Harald von Boehmer and Pawel Kisielow},
  journal={European journal of immunology},
  year={1993},
  volume={23 3},
  pages={
          739-46
        }
}
We have analyzed the inducibility of protein kinase C (PKC)-dependent expression of CD 69 molecules in T cell receptor (TCR) transgenic thymocytes developing in the presence or absence of selecting, class I major histocompatibility complex (MHC) molecules. Small CD4+8+ thymocytes developing in the absence of selecting MHC molecules could not be induced to express CD 69 by TCR cross-linking even after spontaneous in vitro up-regulation of their TCR level which resulted in enhanced Ca++ flux. In… CONTINUE READING
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