CD69, an early activation antigen on lymphocytes, is constitutively expressed by human epidermal Langerhans cells.

@article{Bieber1992CD69AE,
  title={CD69, an early activation antigen on lymphocytes, is constitutively expressed by human epidermal Langerhans cells.},
  author={Thomas Bieber and Attain Rieger and Georg Stingl and Erich Sander and Paul Wanek and I. Strobel},
  journal={The Journal of investigative dermatology},
  year={1992},
  volume={98 5},
  pages={771-6}
}
When screening skin cryosections with a panel of monoclonal antibodies (MoAb), we found that the anti-CD69 MoAb Leu-23 reacted with a subpopulation of epidermal dendritic cells, presumably Langerhans cells (LC). The staining intensity was enhanced by gentle trypsin pretreatment of the sections. Flow cytometric analysis of LC-enriched epidermal cells (EC) revealed that nearly all CD1a-bearing LC display anti-CD69 reactivity when tested briefly after termination of the enrichment procedure… CONTINUE READING

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