CD66-dependent neutrophil activation: a possible mechanism for vascular selectin-mediated regulation of neutrophil adhesion.

@article{Stocks1995CD66dependentNA,
  title={CD66-dependent neutrophil activation: a possible mechanism for vascular selectin-mediated regulation of neutrophil adhesion.},
  author={Stefan Stocks and Michael A. Kerr and Christopher Haslett and Ian Dransfield},
  journal={Journal of leukocyte biology},
  year={1995},
  volume={58 1},
  pages={
          40-8
        }
}
We have examined the role of CD66 in the modulation of neutrophil adhesion and effector function. Engagement of neutrophil CD66 with anti-carcinoembryonic antigen (anti-CEA) Ig results in activation-associated phenomena including shape change, activation of beta 2-integrins, and priming of the respiratory burst. Anti-CEA Ig-treated neutrophils underwent transient shape change distinct from that induced by formyl-Met-Leu-Phe (fMLP). fMLP stimulated beta 2-integrin up-regulation and 70% loss of L… CONTINUE READING

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