CD64-directed microtubule associated protein tau kills leukemic blasts ex vivo

@inproceedings{Mladenov2016CD64directedMA,
  title={CD64-directed microtubule associated protein tau kills leukemic blasts ex vivo
},
  author={Radoslav Mladenov and Dmitrij Hristodorov and Christian Cremer and Gerrit Gresch and Elena Grieger and L. Diane Schenke and Diana Klose and Manal Amoury and Mira Woitok and Edgar Jost and Tim H. Br{\"u}mmendorf and Rolf Fendel and Reinhard Fischer and Christoph W. Stein and Theo Thepen and Stefan Barth},
  booktitle={Oncotarget},
  year={2016}
}
Fc gamma receptor I (FcγRI, CD64) is a well-known target antigen for passive immunotherapy against acute myeloid leukemia and chronic myelomonocytic leukemia. We recently reported the preclinical immunotherapeutic potential of microtubule associated protein tau (MAP) against a variety of cancer types including breast carcinoma and Hodgkin's lymphoma. Here we demonstrate that the CD64-directed human cytolytic fusion protein H22(scFv)-MAP kills ex vivo 15-50% of CD64+ leukemic blasts derived from… CONTINUE READING
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