CD6 attenuates early and late signaling events, setting thresholds for T-cell activation

@inproceedings{Oliveira2012CD6AE,
  title={CD6 attenuates early and late signaling events, setting thresholds for T-cell activation},
  author={Marta I Oliveira and Carine Machado Gonçalves and Mafalda Mendes Pinto and St{\'e}phanie Fabre and Ant{\'o}nio M{\'a}rio Santos and Simon F K Lee and M{\'o}nica Alejandra Maya Castro and Raquel J. Nunes and Rita R. Barbosa and Jane R. Parnes and C. T. Yu and Simon J Davis and Alexandra Moreira and Georges Bismuth and Alexandre M Carmo},
  booktitle={European journal of immunology},
  year={2012}
}
The T lineage glycoprotein CD6 is generally considered to be a costimulator of T-cell activation. Here, we demonstrate that CD6 significantly reduces early and late T-cell responses upon superantigen stimulation or TCR triggering by Abs. Measuring calcium mobilization in single cells responding to superantigen, we found that human T cells expressing rat CD6 react significantly less well compared with T cells not expressing the exogenous receptor. When the cytoplasmic domain of rat CD6 was… CONTINUE READING
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