CD59 functions as a signal-transducing molecule for human T cell activation.

  title={CD59 functions as a signal-transducing molecule for human T cell activation.},
  author={P E Korty and C Brando and Ethan M Shevach},
  journal={Journal of immunology},
  volume={146 12},
The CD59 Ag is a 20-kDa protein that is widely expressed on most leukocytes and RBC, is coupled to the membrane by a phosphatidylinositol-glycan anchoring structure, plays a role in cell interaction between monocytes and T cells, and also functions as an inhibitor of cytolysis by the terminal C components C5b-9. Because this molecule is structurally related to the murine Ly-6 family of Ag, we have investigated whether anti-CD59 mAb might be capable of activating human T lymphocytes in a manner… CONTINUE READING

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