CD56+ immune cell infiltration and MICA are decreased in breast lobules with fibrocystic changes

@inproceedings{Kerekes2017CD56IC,
  title={CD56+ immune cell infiltration and MICA are decreased in breast lobules with fibrocystic changes},
  author={Daniel Kerekes and Daniel W. Visscher and Tanya L. Hoskin and Derek C. Radisky and Rushin D. Brahmbhatt and Alvaro Manuel Ramos Pe{\~n}a and Marlene H. Frost and Muhammad Irshad Arshad and Melody L. Stallings-Mann and Stacey J Winham and Linda Mary Murphy and Lori A. Denison and Jodi M. Carter and Keith L. Knutson and Amy C Degnim},
  booktitle={Breast Cancer Research and Treatment},
  year={2017}
}
PurposeWhile the role of natural killer (NK) cells in breast cancer therapy has been investigated, little information is known about NK cell function and presence in nonmalignant and premalignant breast tissue. Here, we investigate and quantify NK cell marker CD56 and activating ligand MICA in breast tissue with benign breast disease.MethodsSerial tissue sections from 88 subjects, 44 with benign breast disease (BBD) who remained cancer-free, and 44 with BBD who later developed cancer, were… CONTINUE READING
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Alterations in the Immune Cell Composition in Premalignant Breast Tissue that Precede Breast Cancer Development.

  • Clinical cancer research : an official journal of the American Association for Cancer Research
  • 2017
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