CD5 is A potential selecting ligand for B-cell surface immunoglobulin: a possible role in maintenance and selective expansion of normal and malignant B cells.

@article{Pospisil2000CD5IA,
  title={CD5 is A potential selecting ligand for B-cell surface immunoglobulin: a possible role in maintenance and selective expansion of normal and malignant B cells.},
  author={Richard Pospisil and Gregg J Silverman and Gerald E. Marti and Alejandro Aruffo and Michael A. Bowen and Rose G. Mage},
  journal={Leukemia & lymphoma},
  year={2000},
  volume={36 3-4},
  pages={
          353-65
        }
}
Although the function of CD5 on B cells is unknown, previous studies suggested that CD5 interaction with V(H) framework regions of surface immunoglobulins (Igs) may contribute to survival and expansion of B cells. Here we used B-chronic lymphocytic leukemia (B-CLL) cells and transformed B-cell lines from normal and B-CLL patients to study CD5-Ig interactions. Immobilized Ig binds and permits isolation of CD5 from lysates of CD5-expressing cell lines. Immunoglobulins or Fab fragments of… CONTINUE READING
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