CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation.

@article{Wit2011CD5CI,
  title={CD5 costimulation induces stable Th17 development by promoting IL-23R expression and sustained STAT3 activation.},
  author={Jelle de Wit and Yuri Souwer and Astrid J van Beelen and Rosa de Groot and Femke J. M. Muller and Hanny Klaasse Bos and Tineke Jorritsma and Martien L. Kapsenberg and Esther C de Jong and S. Marieke van Ham},
  journal={Blood},
  year={2011},
  volume={118 23},
  pages={6107-14}
}
IL-17-producing CD4(+) T helper (Th17) cells are important for immunity against extracellular pathogens and in autoimmune diseases. The factors that drive Th17 development in human remain a matter of debate. Here we show that, compared with classic CD28 costimulation, alternative costimulation via the CD5 or CD6 lymphocyte receptors forms a superior pathway for human Th17-priming. In the presence of the Th17-promoting cytokines IL-1β, IL-6, IL-23, and transforming growth factor-β (TGF-β), CD5… CONTINUE READING