CD5+ B cells from individuals with systemic lupus erythematosus express granzyme B.

@article{Hagn2010CD5BC,
  title={CD5+ B cells from individuals with systemic lupus erythematosus express granzyme B.},
  author={Magdalena Hagn and Verena Ebel and Kai Sontheimer and Elisabeth Schwesinger and Oleg Lunov and Thamara Beyer and Dorit Fabricius and Thomas F E Barth and Andreas a Viardot and Stephan Stilgenbauer and Julia Hepp and Karin Scharffetter-Kochanek and Thomas Simmet and Bernd Jahrsdoerfer},
  journal={European journal of immunology},
  year={2010},
  volume={40 7},
  pages={2060-9}
}
Recently, we reported that IL-21 induces granzyme B (GzmB) and GzmB-dependent apoptosis in malignant CD5(+) B cells from patients with chronic lymphocytic leukemia. Several autoimmune diseases (AD) are associated with enhanced frequencies of CD5(+) B cells. Since AD are also associated with elevated IL-21 and GzmB levels, we postulated a link between CD5(+) B cells, IL-21 and GzmB. Here, we demonstrate that IL-21 and GzmB serum levels are highly correlated in subjects with systemic lupus… CONTINUE READING

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