CD49f and CD61 identify Her2/neu-induced mammary tumor initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling

@inproceedings{Lo2012CD49fAC,
  title={CD49f and CD61 identify Her2/neu-induced mammary tumor initiating cells that are potentially derived from luminal progenitors and maintained by the integrin-TGFβ signaling},
  author={Pang-Kuo Lo and Deepak Kanojia and Xinfeng Liu and Udai P Singh and Franklin G. Berger and Qian Wang and H Chen},
  booktitle={Oncogene},
  year={2012}
}
Human epidermal growth factor receptor 2 (HER2)/Neu is overexpressed in 20–30% of breast cancers and associated with aggressive phenotypes and poor prognosis. For deciphering the role of HER2/Neu in breast cancer, mouse mammary tumor virus (MMTV)-Her2/neu transgenic mice that develop mammary tumors resembling human HER2-subtype breast cancer have been established. Several recent studies have revealed that HER2/Neu is overexpressed in and regulates self renewal of breast tumor-initiating cells… CONTINUE READING

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