CD47 in the tumor microenvironment limits cooperation between antitumor T-cell immunity and radiotherapy.

@article{SotoPantoja2014CD47IT,
  title={CD47 in the tumor microenvironment limits cooperation between antitumor T-cell immunity and radiotherapy.},
  author={David R Soto-Pantoja and Masaki Terabe and Arunima Ghosh and Lisa A. Ridnour and William G Degraff and David A Wink and Jay A. Berzofsky and David D. Roberts},
  journal={Cancer research},
  year={2014},
  volume={74 23},
  pages={6771-83}
}
Although significant advances in radiotherapy have increased its effectiveness in many cancer settings, general strategies to widen the therapeutic window between normal tissue toxicity and malignant tumor destruction would still offer great value. CD47 blockade has been found to confer radioprotection to normal tissues while enhancing tumor radiosensitivity. Here, we report that CD47 blockade directly enhances tumor immunosurveillance by CD8(+) T cells. Combining CD47 blockade with irradiation… CONTINUE READING

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Cancer immunotherapy targeting the CD47/SIRPα axis.

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Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective antitumor T-cell response.

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