CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cells.

@article{Yanagi1996CD45MP,
  title={CD45 modulates phosphorylation of both autophosphorylation and negative regulatory tyrosines of Lyn in B cells.},
  author={Shigeru Yanagi and Hiroshi Sugawara and Mari Kurosaki and H. Sabe and Hirohei Yamamura and Tomohiro Kurosaki},
  journal={The Journal of biological chemistry},
  year={1996},
  volume={271 48},
  pages={30487-92}
}
CD45 is a tyrosine phosphatase that is required for normal B cell receptor (BCR)-mediated signaling. It has been shown that Src-family tyrosine kinases such as Lyn could be a potential substrate for CD45. In vitro studies indicate that activities of Src family tyrosine kinases are regulated by tyrosine phosphorylation; C-terminal phosphorylation is inhibitory, and autophosphorylation is stimulatory. We report here that both autophosphorylation and C-terminal negative regulatory tyrosines of Lyn… CONTINUE READING
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