CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: implications for T cell memory.

@article{Cossarizza1996CD45IE,
  title={CD45 isoforms expression on CD4+ and CD8+ T cells throughout life, from newborns to centenarians: implications for T cell memory.},
  author={Andrea Cossarizza and Claudio Ortolani and Roberto Paganelli and Daniela Barbieri and Daniela Monti and Paolo Sansoni and Umberto Fagiolo and Gastone Castellani and F. Bersani and Marco Londei and Claudio Franceschi},
  journal={Mechanisms of ageing and development},
  year={1996},
  volume={86 3},
  pages={173-95}
}
CD4+ and CD8+ peripheral blood T lymphocytes show mutually exclusive expression of CD45RA or CD45R0, two isoforms of the common leukocyte antigen that seem to recognize so-called virgin/unprimed and memory/activated T cells. The expression of these isoforms has been studied by three colour cytofluorimetric analysis on CD4+ or CD8+ peripheral blood CD3+ cells from 22 healthy centenarians, analyzed in a context of 202 healthy donors 0-110 years old. An age-related unbalance of virgin and memory… CONTINUE READING