CD45 isoform transitions on multinegative human thymocytes differentiating in vitro mimic patterns predicted for selective events in vivo.

@article{Pilarski1993CD45IT,
  title={CD45 isoform transitions on multinegative human thymocytes differentiating in vitro mimic patterns predicted for selective events in vivo.},
  author={Linda M. Pilarski and Julie P. Deans},
  journal={Immunology and cell biology},
  year={1993},
  volume={71 ( Pt 4)},
  pages={
          289-301
        }
}
Experiments were designed to test the idea that the patterns of CD45 isoform expressed by differentiating human multinegative (MN) thymocytes (CD3- 4- 8- 19-) are regulated by the type of growth or activation stimuli delivered. We have proposed that within the thymus, CD45RA expression is fundamental to maintenance of the thymic generative lineage while a transition to CD45RO indicates entry into the path of intrathymic death. It seems likely that the signal transduction pathways leading to… CONTINUE READING
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