CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling

  title={CD45 is a JAK phosphatase and negatively regulates cytokine receptor signalling},
  author={Junko Irie-Sasaki and Takehiko Sasaki and Wataru Matsumoto and Anne Opavsky and Mary Cheng and G. Grant Welstead and Emily K. Griffiths and Connie M. Krawczyk and Christopher Donald Richardson and Karen J. Aitken and Norman N. Iscove and Gary A. Koretzky and Pauline Johnson and Peter Liu and David M. Rothstein and Josef M. Penninger},
The regulation of tyrosine phosphorylation and associated signalling through antigen, growth-factor and cytokine receptors is mediated by the reciprocal activities of protein tyrosine kinases and protein tyrosine phosphatases (PTPases). The transmembrane PTPase CD45 is a key regulator of antigen receptor signalling in T and B cells. Src-family kinases have been identified as primary molecular targets for CD45 (ref. 4). However, CD45 is highly expressed in all haematopoietic lineages at all… 

The secret of CD45

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