CD45 glycosylation controls T-cell life and death.

  title={CD45 glycosylation controls T-cell life and death.},
  author={Lesley A. Earl and Linda G. Baum},
  journal={Immunology and cell biology},
  volume={86 7},
CD45, an abundant and highly glycosylated cell-surface protein, is a critical regulator of T-cell development. CD45 is differentially glycosylated throughout the life of a T cell, and the glycosylation state of CD45 controls recognition by various binding partners, affects intracellular signaling by the cytoplasmic tyrosine phosphatase domain and modulates the response of the T cell to antigen. Although the importance of CD45 during T-cell development has been established, it is becoming… CONTINUE READING


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