CD45: a critical regulator of signaling thresholds in immune cells.

  title={CD45: a critical regulator of signaling thresholds in immune cells.},
  author={Michelle L. Hermiston and Zheng Xu and Arthur Weiss},
  journal={Annual review of immunology},
Regulation of tyrosine phosphorylation is a critical control point for integration of environmental signals into cellular responses. This regulation is mediated by the reciprocal actions of protein tyrosine kinases and phosphatases. CD45, the first and prototypic receptor-like protein tyrosine phosphatase, is expressed on all nucleated hematopoietic cells and plays a central role in this process. Studies of CD45 mutant cell lines, CD45-deficient mice, and CD45-deficient humans initially… CONTINUE READING
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