CD44 targets Na+/H+ exchanger 1 to mediate MDA-MB-231 cells' metastasis via the regulation of ERK1/2

@inproceedings{Chang2014CD44TN,
  title={CD44 targets Na+/H+ exchanger 1 to mediate MDA-MB-231 cells' metastasis via the regulation of ERK1/2},
  author={Guoqiang Chang and Jingfeng Wang and Yu Zhang and Changyuan Wang and Hongfa Xu and Huilin Zhang and Yuan Cheng Lin and Lang Ma and Qi Li and Tao Pang},
  booktitle={British Journal of Cancer},
  year={2014}
}
Background:CD44, a transmembrane glycoprotein expressed in a variety of cells and tissues, has been implicated in tumour metastasis. But the molecular mechanisms of CD44-mediated tumour cell metastasis remain to be elucidated.Methods:The downregulation of CD44 was determined by immunofluorescence. Moreover, the motility of breast cancer cells was detected by wound-healing and transwell experiments. Then the spontaneous metastasis of CD44-silenced MDA-MB-231 cells was tested by histology with… CONTINUE READING
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