CD44 targeted chemotherapy for co-eradication of breast cancer stem cells and cancer cells using polymeric nanoparticles of salinomycin and paclitaxel.

@article{Muntimadugu2016CD44TC,
  title={CD44 targeted chemotherapy for co-eradication of breast cancer stem cells and cancer cells using polymeric nanoparticles of salinomycin and paclitaxel.},
  author={Eameema Muntimadugu and Rajendra Kumar and Shantikumar Saladi and Towseef Amin Rafeeqi and Wahid Khan},
  journal={Colloids and surfaces. B, Biointerfaces},
  year={2016},
  volume={143},
  pages={
          532-546
        }
}
This combinational therapy is mainly aimed for complete eradication of tumor by killing both cancer cells and cancer stem cells. Salinomycin (SLM) was targeted towards cancer stem cells whereas paclitaxel (PTX) was used to kill cancer cells. Drug loaded poly (lactic-co-glycolic acid) nanoparticles were prepared by emulsion solvent diffusion method using cationic stabilizer. Size of the nanoparticles (below 150nm) was determined by dynamic light scattering technique and transmission electron… CONTINUE READING

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  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2018
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