CD44-specific supramolecular hydrogels for fluorescence molecular imaging of stem-like gastric cancer cells.

@article{Park2013CD44specificSH,
  title={CD44-specific supramolecular hydrogels for fluorescence molecular imaging of stem-like gastric cancer cells.},
  author={Jungmin Park and Minhee Ku and Eunjung Kim and Yeonji Park and Yoochan Hong and Seungjoo Haam and Jae Ho Cheong and Eun Sung Park and Jin-Suck Suh and Young Duk Huh and Jaemoon Yang},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2013},
  volume={5 4},
  pages={
          669-72
        }
}
We describe a near-infrared-sensitive molecular imaging probe based on hydrogel complexes that can target a stem-like gastric cancer cell marker (CD44, a marker that often correlates with a poor prognosis in patients). Thus, CD44-targetable and near-infrared-sensitive supramolecular hydrogels (NIRSHs, Cy5.5-conjugated polyethyleneimine/hyaluronic acid polyplexes) were fabricated by polyplexing in an aqueous medium. NIRSHs demonstrated good water-stability, biocompatibility, and specificity to… CONTINUE READING
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