CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin.

@article{Singleton2007CD44RH,
  title={CD44 regulates hepatocyte growth factor-mediated vascular integrity. Role of c-Met, Tiam1/Rac1, dynamin 2, and cortactin.},
  author={Patrick A. Singleton and Ravi Salgia and Liliana Moreno-Vinasco and Jaideep Moitra and Saad Sammani and Tamara Mirzapoiazova and Joe G. N. Garcia},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 42},
  pages={30643-57}
}
The preservation of vascular endothelial cell (EC) barrier integrity is critical to normal vessel homeostasis, with barrier dysfunction being a feature of inflammation, tumor angiogenesis, atherosclerosis, and acute lung injury. Therefore, agents that preserve or restore vascular integrity have important therapeutic implications. In this study, we explored the regulation of hepatocyte growth factor (HGF)-mediated enhancement of EC barrier function via CD44 isoforms. We observed that HGF… CONTINUE READING

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