CD44 positive macrophages take up hyaluronan during lung development.

  title={CD44 positive macrophages take up hyaluronan during lung development.},
  author={Charles B. Underhill and Hoa A. Nguyen and M Shizari and Martine Culty},
  journal={Developmental biology},
  volume={155 2},
In the present study, we examined the expression and distribution of both hyaluronan and its cell-surface receptor (CD44) during lung development in the mouse. Hyaluronan was detected by a specific binding probe, termed b-PG, which is a biotinylated mixture of proteoglycan and link protein from cartilage. Using this probe in an enzyme-linked assay, the amount of hyaluronan in relation to protein content was found to decrease as lung development progressed. In addition, histochemical staining of… CONTINUE READING
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