CD44 mediates human glioma cell adhesion and invasion in vitro.

  title={CD44 mediates human glioma cell adhesion and invasion in vitro.},
  author={Abderrahim Merzak and S. Koocheckpour and Geoffrey J. Pilkington},
  journal={Cancer research},
  volume={54 15},
Human gliomas are characterized by their invasion of normal brain structures irrespective of their grade of malignancy. Factors involved in the control of this invasive behavior are poorly documented. Human gliomas have also been found to express CD44 adhesion molecules. Expression of splice variants of CD44 has been correlated to metastasis in nonglial solid tumors. In this study, 8-microns porosity polycarbonate filters incorporated in modified Boyden chambers and coated with the… CONTINUE READING
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