CD44 ligation induces caspase-independent cell death via a novel calpain/AIF pathway in human erythroleukemia cells

@article{Artus2006CD44LI,
  title={CD44 ligation induces caspase-independent cell death via a novel calpain/AIF pathway in human erythroleukemia cells},
  author={C{\'e}dric Artus and Eliane Maquarre and Rana S. Moubarak and C{\'e}cile Delettre and Claude Jasmin and Santos A Susin and Jacqueline Robert-L{\'e}z{\'e}n{\`e}s},
  journal={Oncogene},
  year={2006},
  volume={25},
  pages={5741-5751}
}
Ligation of the cell surface molecule CD44 by anti-CD44 monoclonal antibodies (mAbs) has been shown to induce cell differentiation, cell growth inhibition and in some cases, apoptosis in myeloid leukemic cells. We report, herein, that exposure of human erythroleukemic HEL cells to the anti-CD44 mAb A3D8 resulted in cell growth inhibition followed by caspase-independent apoptosis-like cell death. This process was associated with the disruption of mitochondrial membrane potential (ΔΨm), the… CONTINUE READING
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