CD44 knock-down in bovine and human chondrocytes results in release of bound HYAL2.

@article{Hida2015CD44KI,
  title={CD44 knock-down in bovine and human chondrocytes results in release of bound HYAL2.},
  author={Daisuke Hida and Ben T Danielson and Cheryl B. Knudson and Warren Knudson},
  journal={Matrix biology : journal of the International Society for Matrix Biology},
  year={2015},
  volume={48},
  pages={42-54}
}
CD44 shedding occurs in osteoarthritic chondrocytes. Previous work of others has suggested that the hyaluronidase isoform HYAL2 has the capacity to bind to CD44, a binding that may itself induce CD44 cleavage. Experiments were developed to elucidate whether chondrocyte HYAL2: (1) was exposed on the extracellular plasma membrane of chondrocytes, (2) bound to… CONTINUE READING