CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex.

@article{Shi2006CD44IT,
  title={CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex.},
  author={Xuerong Shi and Lin Leng and Tian Wang and Wenkui Wang and Xin Du and Ji Li and Courtney McDonald and Zun Chen and James W. Murphy and Elias Lolis and Paul James Noble and Warren Knudson and Richard Bucala},
  journal={Immunity},
  year={2006},
  volume={25 4},
  pages={595-606}
}
The macrophage migration inhibitory factor (MIF) receptor (CD74) was cloned recently, but the signaling mechanism is not evident. We hypothesized that signaling requires an additional molecule such as CD44, which activates nonreceptor tyrosine kinases. We utilized the CD74- and CD44-deficient COS-7/M6 cell to create stable transfectants expressing CD74, CD44, and a truncated CD44 lacking its intracytoplasmic signaling domain. CD74 alone mediated MIF binding; however, MIF-induced ERK1 and ERK2… CONTINUE READING
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