CD44 is a determinant of inflammatory bone loss

  title={CD44 is a determinant of inflammatory bone loss},
  author={Silvia Hayer and Guenter Steiner and Birgit G{\"o}rtz and Erika Reiter and Makiyeh Tohidast-Akrad and Michael Amling and Oskar Hoffmann and Kurt Redlich and Jochen Zwerina and Karl Skriner and Frank Hilberg and Erwin F Wagner and Josef S Smolen and Georg Schett},
  journal={The Journal of Experimental Medicine},
  pages={903 - 914}
Chronic inflammation is a major trigger of local and systemic bone loss. Disintegration of cell-matrix interaction is a prerequisite for the invasion of inflammatory tissue into bone. CD44 is a type I transmembrane glycoprotein that connects a variety of extracellular matrix proteins to the cell surface. Tumor necrosis factor (TNF) is a major inducer of chronic inflammation and its overexpression leads to chronic inflammatory arthritis. By generating CD44(-/-) human TNF-transgenic (hTNFtg) mice… CONTINUE READING
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