CD44-independent activation of the Met signaling pathway by HGF and InlB.

@article{Dortet2010CD44independentAO,
  title={CD44-independent activation of the Met signaling pathway by HGF and InlB.},
  author={Laurent Dortet and Esteban Veiga and Matteo Bonazzi and Pascale Cossart},
  journal={Microbes and infection},
  year={2010},
  volume={12 12-13},
  pages={919-27}
}
Listeria monocytogenes is a facultative intracellular Gram-positive bacterium responsible for listeriosis. It is able to invade, survive and replicate in phagocytic and non-phagocytic cells. The L. monocytogenes surface protein InlB interacts with c-Met, the hepatocyte growth factor (HGF) receptor, inducing bacterial internalization in numerous non-phagocytic cells. As InlB and HGF are known to trigger similar signaling pathways upon c-Met activation, we investigated the role of CD44, and more… CONTINUE READING