CD44 in human placenta: localization and binding to hyaluronic acid.

@article{Jacques1993CD44IH,
  title={CD44 in human placenta: localization and binding to hyaluronic acid.},
  author={S St Jacques and Harjit K Dadi and Michelle Letarte},
  journal={Placenta},
  year={1993},
  volume={14 1},
  pages={25-39}
}
CD44, a receptor for hyaluronic acid (HA), has been identified in the stroma of stem and terminal chorionic villi of human term placenta. The CD44 glycoprotein antigen, isolated from placenta by affinity to monoclonal antibody (mAb) 50B4, consisted mainly of species of M(r) 85,000 and 200,000. Radiolabelled CD44 bound specifically to HA attached to plastic, predominantly via the M(r) 85,000 species; this binding was inhibited by soluble HA and hyaluronidase. The binding of CD44 to HA was also… CONTINUE READING

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