CD44 expression in endothelial colony-forming cells regulates neurovascular trophic effect.

@article{Sakimoto2017CD44EI,
  title={CD44 expression in endothelial colony-forming cells regulates neurovascular trophic effect.},
  author={Susumu Sakimoto and Valentina Marchetti and Edith Aguilar and Kelsey Lee and Yoshihiko Usui and Salome Murinello and Felicitas Bucher and Jennifer K Trombley and Regis Fallon and Ravenska T. E. Wagey and Carrie Peters and Elizabeth L Scheppke and Peter D. Westenskow and Martin Friedlander},
  journal={JCI insight},
  year={2017},
  volume={2 2},
  pages={e89906}
}
Vascular abnormalities are a common component of eye diseases that often lead to vision loss. Vaso-obliteration is associated with inherited retinal degenerations, since photoreceptor atrophy lowers local metabolic demands and vascular support to those regions is no longer required. Given the degree of neurovascular crosstalk in the retina, it may be possible to use one cell type to rescue another cell type in the face of severe stress, such as hypoxia or genetically encoded cell-specific… CONTINUE READING

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