CD44 drives aggressiveness and chemoresistance of a metastatic human osteosarcoma xenograft model

Abstract

Background Osteosarcoma is the most common primary malignant bone tumor with a 5 year survival rate of up to 70%. However, patients with metastatic disease have still a very poor prognosis. Osteosarcoma metastasis models are essential to develop novel treatment strategies for advanced disease. Methods Based on a serial transplantation approach, we have… (More)
DOI: 10.18632/oncotarget.23125

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