CD44 and TLR4 mediate hyaluronic acid regulation of Lgr5+ stem cell proliferation, crypt fission, and intestinal growth in postnatal and adult mice.

@article{Riehl2015CD44AT,
  title={CD44 and TLR4 mediate hyaluronic acid regulation of Lgr5+ stem cell proliferation, crypt fission, and intestinal growth in postnatal and adult mice.},
  author={Terrence E. Riehl and Srikanth K Santhanam and Lynne Foster and Matthew A. Ciorba and William F. Stenson},
  journal={American journal of physiology. Gastrointestinal and liver physiology},
  year={2015},
  volume={309 11},
  pages={G874-87}
}
Hyaluronic acid, a glycosaminoglycan in the extracellular matrix, binds to CD44 and Toll-like receptor 4 (TLR4). We previously addressed the role of hyaluronic acid in small intestinal and colonic growth in mice. We addressed the role of exogenous hyaluronic acid by giving hyaluronic acid intraperitoneally and the role of endogenous hyaluronic acid by giving PEP-1, a peptide that blocks hyaluronic acid binding to its receptors. Exogenous hyaluronic acid increased epithelial proliferation but… CONTINUE READING
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