CD44 Plays a Functional Role in Helicobacter pylori-induced Epithelial Cell Proliferation

@inproceedings{BertauxSkeirik2015CD44PA,
  title={CD44 Plays a Functional Role in Helicobacter
pylori-induced Epithelial Cell Proliferation},
  author={Nina Bertaux-Skeirik and Rui Feng and Michael A. Schumacher and Jing Rong Li and Maxime M Mahe and Amy Christine Engevik and Jose E. Javier and Richard M. Peek and Karen M Ottemann and V{\'e}ronique Orian-Rousseau and Gregory P. Boivin and Michael A. Helmrath and Yana Zavros and Steven Robert Blanke},
  booktitle={PLoS pathogens},
  year={2015}
}
The cytotoxin-associated gene (Cag) pathogenicity island is a strain-specific constituent of Helicobacter pylori (H. pylori) that augments cancer risk. CagA translocates into the cytoplasm where it stimulates cell signaling through the interaction with tyrosine kinase c-Met receptor, leading cellular proliferation. Identified as a potential gastric stem cell marker, cluster-of-differentiation (CD) CD44 also acts as a co-receptor for c-Met, but whether it plays a functional role in H. pylori… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 36 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 53 REFERENCES

Similar Papers

Loading similar papers…