CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis.

@article{Ishimoto2010CD44ST,
  title={CD44+ slow-cycling tumor cell expansion is triggered by cooperative actions of Wnt and prostaglandin E2 in gastric tumorigenesis.},
  author={Takatsugu Ishimoto and Hiroko Oshima and Masanobu Oshima and Kazuharu Kai and Ryota Torii and Takashi Masuko and Hideo Baba and Hideyuki Saya and Osamu Nagano},
  journal={Cancer science},
  year={2010},
  volume={101 3},
  pages={673-8}
}
Similar to normal tissue stem cells, cancer stem cells (CSCs) are thought to be quiescent or slow-cycling and, thereby, insensitive to chemo- and radiotherapies. CD44, a cell surface component that interacts with the extracellular matrix, has been found to be highly expressed in CSCs of several solid tumors. However, the relevancy between CD44(+) cells and slow-cycling cells and the underlying mechanisms for the emergence of CD44(+) CSCs during tumorigenesis have not been elucidated. Here we… CONTINUE READING