CD44+ Cancer Stem-Like Cells in EBV-Associated Nasopharyngeal Carcinoma

  title={CD44+ Cancer Stem-Like Cells in EBV-Associated Nasopharyngeal Carcinoma},
  author={Samantha Wei-Man Lun and Siu Tim Cheung and Phyllis Fung Yi Cheung and Ka-fai To and John Kong-Sang Woo and K D K Y Choy and Chit Chow and Chartia Ching-Mei Cheung and Grace Tin-Yun Chung and Alice Suk-Hang Cheng and Chun-Wai Ko and Sai-wah Tsao and Pierre Busson and Margaret H L Ng and K. D. Lo},
  booktitle={PloS one},
Nasopharyngeal carcinoma (NPC) is a unique EBV-associated epithelial malignancy, showing highly invasive and metastatic phenotype. Despite increasing evidence demonstrating the critical role of cancer stem-like cells (CSCs) in the maintenance and progression of tumors in a variety of malignancies, the existence and properties of CSC in EBV-associated NPC are largely unknown. Our study aims to elucidate the presence and role of CSCs in the pathogenesis of this malignant disease. Sphere-forming… CONTINUE READING
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