CD43 has a functional NLS, interacts with beta-catenin, and affects gene expression.

@article{Andersson2004CD43HA,
  title={CD43 has a functional NLS, interacts with beta-catenin, and affects gene expression.},
  author={Christian X. Andersson and J. J. Fernandez-Rodriguez and Sirle Laos and Rein Sikut and Anu Sikut and Dan Baeckstr{\"o}m and Gunnar C Hansson},
  journal={Biochemical and biophysical research communications},
  year={2004},
  volume={316 1},
  pages={12-7}
}
CD43 is a transmembrane molecule with a highly O-glycosylated extracellular domain of mucin type. It is a normal constituent of leukocytes and found in colon adenoma, but not in normal colon epithelia. Here it is shown that the cytoplasmic tail of CD43 contains a functional bipartite nuclear localization signal directing it to the nucleus. The intracellular domain of CD43 interacts with beta-catenin and causes an upregulation of the beta-catenin target genes c-MYC and CyclinD1. The present… CONTINUE READING
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