CD43 functions as a ligand for E-Selectin on activated T cells.

  title={CD43 functions as a ligand for E-Selectin on activated T cells.},
  author={Masanori Matsumoto and Kazuyuki Atarashi and Eiji Umemoto and Yuko Furukawa and Akiko Shigeta and Masayuki Miyasaka and Takako Hirata},
  journal={Journal of immunology},
  volume={175 12},
E-selectin, an inducible cell adhesion molecule expressed on endothelial cells, mediates the rolling on endothelium of leukocytes expressing E-selectin ligands, such as neutrophils and activated T cells. Although previous studies using mice lacking P-selectin glycoprotein ligand-1 (PSGL-1) have indicated that PSGL-1 on Th1 cells functions as an E-selectin ligand, the molecular nature of E-selectin ligands other than PSGL-1 remains unknown. In this study, we show that a 130-kDa glycoprotein was… CONTINUE READING


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